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Grant Award View - GA289031
MEGA-dose aSCORbatE for Sepsis (MEGASCORES): An interdisciplinary...
GA ID:
GA289031
Agency:
Department of Health and Aged Care
Approval Date:
13-Dec-2022
Publish Date:
20-Mar-2023
Category:
Medical Research
Grant Term:
1-Feb-2023 to 31-Mar-2028
Value (AUD):
$4,897,652.65
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
DoHAC 22/23 1.1 Health Policy Research and Analysis
Grant Program:
Medical Research Future Fund
Grant Activity:
MEGA-dose aSCORbatE for Sepsis (MEGASCORES): An interdisciplinary research program to transform management of sepsis in intensive care units
Purpose:
One in five people die due to sepsis when infection causes organ failure.
Ascorbic acid (vitamin C) may be an effective therapy, but clinical trials to date have failed to show benefit, likely due to inadequate dosing and acidity.
We reported a dramatic reversal of sepsis when mega-doses of the sodium salt of vitamin C is used. Our expert team will conduct a series of studies in animals and then humans to define how sodium ascorbate reverses sepsis and whether this translates to saving lives.
Ascorbic acid (vitamin C) may be an effective therapy, but clinical trials to date have failed to show benefit, likely due to inadequate dosing and acidity.
We reported a dramatic reversal of sepsis when mega-doses of the sodium salt of vitamin C is used. Our expert team will conduct a series of studies in animals and then humans to define how sodium ascorbate reverses sepsis and whether this translates to saving lives.
GO ID:
GO Title:
MRFF - 2021 Early to Mid-Career Researchers Grant Opportunity
Internal Reference ID:
2022/MRF2022388
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Melbourne
Recipient ABN:
84 002 705 224
Grant Recipient Location
Suburb:
Parkville
Town/City:
Parkville
Postcode:
3052
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC, SA
Postcode:
Multiple
Country:
AUSTRALIA