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Archived Grant Opportunity View - GO5569

MRFF – CTAI and EPCDRI 2022 Multiple Sclerosis Research Grant Opportunity

Contact Details

NHMRC Research Help Centre

1800 500 983



National Health and Medical Research Council (NHMRC)
Close Date & Time:
1-Feb-2023 5:00 pm (ACT Local Time)
Show close time for other time zones
Co-sponsored with:
Department of Health and Aged Care
Internal Reference ID:
Primary Category:
231013 - Medical Research
Publish Date:
Selection Process:
Targeted or Restricted Competitive


The objectives of the MRFF 2022 Multiple Sclerosis Research grant opportunity are to support medical research and medical innovation projects that:

  • Stream 1: promote Australian involvement in international collaborative investigator-initiated clinical trials testing the effectiveness of vaccines for prevention of latent Epstein-Barr virus infection through the establishment and coordination of clinical trials site/s in Australia
  • Stream 2: clinical trials to accelerate the development or repurposing of therapeutic candidates (including antivirals) to treat Epstein-Barr virus for the purpose of preventing or treating conditions such as multiple sclerosis
  • Stream 3: characterise how immune responses to viral infections trigger autoimmune diseases including multiple sclerosis in some individuals to generate knowledge that supports risk stratification so identified individuals can employ strategies to reduce their chance of developing autoimmune disease
  • Stream 4: develop, implement and/or validate approaches for early intervention in individuals recovering from viral infections that aim to reduce the risk and/or severity of the long-term autoimmune consequences, including multiple sclerosis.

The intended outcome of the research funded by this grant opportunity is outlined in section 1.3 of the grant guidelines.

For this grant opportunity, up to $18.0 million of funding is available over 4 years from 2022-23 for the four Streams of research as outlined in section 1.3.

Applicants to this grant opportunity must propose research that addresses one of the four Streams of research. An application may only be submitted to one of the above four Streams only. Applicants must specify the Stream to which they are applying in their application.

This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health.

Further information on the Medical Research Future Fund is available from the Department of Health website.


Applications will only be accepted from NHMRC approved MRFF Eligible Organisations. A list of NHMRC approved MRFF Eligible Organisations is available from the GrantConnect GO Documents and from the MRFF Eligible Organisations list on the NHMRC website.

Applications must satisfy all the requirements set out in the Medical Research Future Fund (MRFF) CTAI and EPCDRI 2022 Multiple Sclerosis Research Grant Opportunity Guidelines.

Grant Activity Timeframe:

1 July 2028

Total Amount Available (AUD):


Instructions for Application Submission:

Applicants are advised to read the Grant Guidelines thoroughly and liaise with the MRFF Eligible Organisation that will submit the application to identify any specific requirements that the Organisation might have.

Applications must be submitted electronically using NHMRC’s online granting system (Sapphire).

There will be two separate application forms in Sapphire to select from, one for Stream 1-2 and one for Stream 3-4.

Other Instructions:

Minimum Data closes at:

  • Stream 1 and 2 - 5:00 pm (ACT Local Time) on 25 January 2023
  • Stream 3 and 4 – 5:00pm (ACT Local Time) on 16 November 2022

Questions should be submitted no later than:

  • Stream 1 and 2 - 1:00 pm (ACT Local Time) on 25 January 2023
  • Stream 3 and 4 – 1:00pm (ACT Local Time) on 23 November 2022
Addenda Available:

Contact Details

NHMRC Research Help Centre

1800 500 983