To access this element change to forms mode OFF
Grant Award View - GA281517-V1
Redefining the immune landscape of the human ocular surface
GA ID:
GA281517-V1
Agency:
Australian Research Council
Approval Date:
19-Jan-2023
Variation Publish Date:
27-Mar-2024
Variation Date:
27-Mar-2024
Category:
Humanities, Arts and Social Sciences (HASS) Research
Grant Term:
3-Apr-2023 to 2-Apr-2026
Value (AUD):
$652,264.00
(GST inclusive where applicable)
Varies:
GA281517
- Redefining the immune landscape of the human ocular surface
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 22/23 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Redefining the immune landscape of the human ocular surface
Purpose:
At the ocular surface, the cornea and limbus need to mount effective immune responses to maintain corneal transparency for clear vision. The current paradigm is that the human cornea houses the same innate immune cell subsets (dendritic cells and macrophages) as naïve mice in pathogen-free facilities. Our pilot data challenge this premise, with early evidence that innate and adaptive cells (T cells) coexist in normal human corneas. Integrating state-of-the-art techniques, we will advance understanding of immune regulation at the human ocular surface by comprehensively defining immune cell biology and dynamics. We will define the effect of age on immune cells in these tissues, and relationships between the tear proteome and cell behaviours.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2023
Internal Reference ID:
DP23 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Melbourne
Recipient ABN:
84 002 705 224
Grant Recipient Location
Suburb:
UNIVERSITY OF MELBOURNE
Town/City:
UNIVERSITY OF MELBOURNE
Postcode:
3010
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3010
Country:
AUSTRALIA