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Grant Award View - GA28344-V4
Molecular mechanisms of mechanosensation and shape regulation in cells
GA ID:
GA28344-V4
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Variation Publish Date:
14-Mar-2023
Variation Date:
14-Mar-2023
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2019 to 31-Dec-2023
Value (AUD):
$470,000.00
(GST inclusive where applicable)
Varies:
GA28344
- Molecular mechanisms of mechanosensation and shape regulation in cells
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Molecular mechanisms of mechanosensation and shape regulation in cells
Purpose:
This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematical model of the regulation of cell-shape and volume. The project will provide an understanding of mechanisms operating when cells and tissues are succumbing to trauma and invasion, and how to control these processes on a molecular level.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Sydney
Recipient ABN:
15 211 513 464
Grant Recipient Location
Suburb:
FOREST LODGE
Town/City:
FOREST LODGE
Postcode:
2037
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
2037
Country:
AUSTRALIA