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Grant Award View - GA68729
Structural insights into activation, dynamics and bias of GPCRs
GA ID:
GA68729
Agency:
Australian Research Council
Approval Date:
19-Dec-2019
Publish Date:
6-Jan-2020
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
10-Feb-2020 to 9-Feb-2023
Original: 1-Jan-2020 to 31-Dec-2022
Value (AUD):
$424,816.00
(GST inclusive where applicable)
Variations:
- GA68729-V3 - Variation to Grant (14-Oct-2021 )
- GA68729-V2 - Variation to Grant (2-Aug-2021 )
- GA68729-V1 - Variation to Grant (28-Apr-2021 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 19/20 Discovery
Grant Program:
Discovery Early Career Researcher Award
Grant Activity:
Structural insights into activation, dynamics and bias of GPCRs
Purpose:
The project aims to investigate the mechanisms underlying activation, biased agonism and G protein selectivity of G protein-coupled receptors (GPCRs) by utilising the adenosine A1 receptor as a model system. This project expects to generate knowledge in the area of GPCR biology using an interdisciplinary approach including structural biology, pharmacology, biochemistry and protein engineering. The expected outcomes include (i) understanding the structural mechanisms underlying GPCR activation, (ii) biased agonism and (iii) G protein selectivity. This should provide significant benefits, such as advancement of fundamental knowledge in GPCR biology and pharmacology that could also one day lead to therapeutic development.
GO ID:
GO Title:
Discovery Early Career Researcher Award for funding commencing in 2020
Internal Reference ID:
DE20 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Melbourne
Recipient ABN:
84 002 705 224
Grant Recipient Location
Suburb:
UNIVERSITY OF MELBOURNE
Town/City:
UNIVERSITY OF MELBOURNE
Postcode:
3010
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3010
Country:
AUSTRALIA