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Grant Award View - GA29145-V3
Seminal fluid interferon-gamma: a potential inhibitor of reproductive...
GA ID:
GA29145-V3
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Variation Publish Date:
20-Oct-2021
Variation Date:
12-Oct-2021
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
11-Feb-2019 to 10-Feb-2022
Value (AUD):
$490,000.00
(GST inclusive where applicable)
Varies:
GA29145
- Seminal fluid interferon-gamma: a potential inhibitor of reproductive success
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Seminal fluid interferon-gamma: a potential inhibitor of reproductive success
Purpose:
This project aims to investigate mechanisms by which infection, heat stress and psycho-social stress interfere with fertility by inducing a signalling factor in seminal fluid that suppresses female immune adaptation for pregnancy. Factors in seminal fluid in addition to sperm parameters are known to affect male reproductive success, but these are not well defined. The cytokine interferon-gamma (IFNG) is variably present in seminal plasma of several mammalian species. It was recently discovered that IFNG interferes with the female immune response required for reproductive success. This project will investigate how seminal fluid IFNG alters female immune adaptation for pregnancy. This will define how environmental factors induce seminal fluid IFNG and determine whether inhibitory effects of IFNG can be overcome with pharmacological inhibitors to boost reproductive success.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Adelaide
Recipient ABN:
61 249 878 937
Grant Recipient Location
Suburb:
ADELAIDE
Town/City:
ADELAIDE
Postcode:
5000
State/Territory:
SA
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
SA
Postcode:
5000
Country:
AUSTRALIA