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Grant Award View - GA69089-V1
New methods for drug discovery by NMR spectroscopy
GA ID:
GA69089-V1
Agency:
Australian Research Council
Approval Date:
6-Jan-2020
Variation Publish Date:
25-May-2021
Variation Date:
25-May-2021
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
23-Mar-2020 to 22-Mar-2023
Value (AUD):
$526,000.00
(GST inclusive where applicable)
Varies:
GA69089
- New methods for drug discovery by NMR spectroscopy
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 19/20 Discovery
Grant Program:
Discovery Projects
Grant Activity:
New methods for drug discovery by NMR spectroscopy
Purpose:
This project aims to advance nuclear magnetic resonance (NMR) spectroscopy methods in the field of drug discovery. It addresses a long-standing bottleneck for medicinal chemists in drug development: the rapid determination of how ligand molecules bind to proteins, where they bind and their orientation in the binding site. The methods include techniques for the attachment of NMR tags to ligands and target proteins, installation of new unnatural amino acids in proteins, and software for automated assignment of NMR spectra and 3D structure modelling of proteins using sparse distance restraints measured by electron paramagnetic resonance (EPR) spectroscopy. The outcome is to benefit the early stages of drug discovery in the biotech industries.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2020
Internal Reference ID:
DP20 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The Australian National University
Recipient ABN:
52 234 063 906
Grant Recipient Location
Suburb:
ACTON
Town/City:
ACTON
Postcode:
2601
State/Territory:
ACT
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
ACT
Postcode:
2601
Country:
AUSTRALIA