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Grant Award View - GA279513
Functional genetic screen of osteoclasts targeted to risk loci for...
GA ID:
GA279513
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
27-Oct-2022
Publish Date:
23-Jan-2023
Category:
Medical Research
Grant Term:
1-Jan-2023 to 31-Dec-2025
Value (AUD):
$755,914.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 21/22 1.1 Health and Medical Research
Grant Program:
Ideas Grants
Grant Activity:
Functional genetic screen of osteoclasts targeted to risk loci for osteoporosis
Purpose:
Numerous genetic risk variants for osteoporosis, which have been identified through genome-wide association studies and are specifically relevant to osteoclast function, have been partially characterised by our group. We will now use targeted Perturb-seq, which involves pooled CRISPR screens that couple targeted genetic perturbations relevant to the risk loci, with single-cell transcriptomics of the osteoclasts to definitively delineate the mechanism of effect of the variants.
GO ID:
GO Title:
Ideas Grants 2022
Internal Reference ID:
2022/GNT2021290
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Western Australia
Recipient ABN:
37 882 817 280
Grant Recipient Location
Suburb:
Nedlands
Town/City:
Nedlands
Postcode:
6009
State/Territory:
WA
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
ACT, WA
Postcode:
Multiple
Country:
AUSTRALIA