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Grant Award View - GA29110
Engineering a chromatin looping factor for artificial gene regulation
GA ID:
GA29110
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Publish Date:
18-Dec-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2019 to 31-Dec-2023
Original: 1-Jan-2019 to 31-Dec-2021
Value (AUD):
$540,000.00
(GST inclusive where applicable)
Variations:
- GA29110-V4 - Variation to Grant (17-May-2023 )
- GA29110-V3 - Variation to Grant (21-Jun-2022 )
- GA29110-V2 - Variation to Grant (20-Oct-2021 )
- GA29110-V1 - Variation to Grant (2-Aug-2021 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Engineering a chromatin looping factor for artificial gene regulation
Purpose:
This project aims to define mechanisms of chromatin looping and gene activation by a widely expressed mammalian protein. The project will establish if the functions of this protein are modulated by the binding of small molecules, whether it can act in conjunction with closely related proteins, and if post-translational modifications regulate looping and gene activation. Using protein engineering the project will develop synthetic looping factors that can switch on a wide array of target genes. The project aims to answer fundamental questions about how proteins can establish and maintain physical loops in DNA to modulate gene expression. The project will also develop research tools that might ultimately correct diseases caused by the faulty expression of genes.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Sydney
Recipient ABN:
15 211 513 464
Grant Recipient Location
Suburb:
FOREST LODGE
Town/City:
FOREST LODGE
Postcode:
2037
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
2037
Country:
AUSTRALIA