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Grant Award View - GA28725-V5
Multilevel selection and the integrity of mitochondrial DNA
GA ID:
GA28725-V5
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Variation Publish Date:
21-Jun-2022
Variation Date:
21-Jun-2022
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2019 to 31-Dec-2022
Value (AUD):
$440,000.00
(GST inclusive where applicable)
Varies:
GA28725
- Multilevel selection and the integrity of mitochondrial DNA
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Multilevel selection and the integrity of mitochondrial DNA
Purpose:
This project aims to investigate the evolutionary conundrum of how and why organelles remain asexual. The widespread occurrence of sexual reproduction suggests that sex is beneficial to organisms. Yet we all carry an ancient genome that never had sex, the mitochondrial genome (mtDNA). Theory predicts that mtDNA should no longer exist, because without sex it accumulates deleterious mutations and cannot accumulate beneficial ones. Yet mtDNA does not suffer mutational meltdown and is shown to adapt. This project will explain how, proposing that the combination of two traits, uniparental inheritance and multiple genomes per cell, make up for the lack of sex. This project expects to provide an explanation for the evolutionary question of what keeps mitochondria healthy, important as mitochondria affect ageing and health.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Sydney
Recipient ABN:
15 211 513 464
Grant Recipient Location
Suburb:
FOREST LODGE
Town/City:
FOREST LODGE
Postcode:
2037
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
2037
Country:
AUSTRALIA