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Grant Award View - GA28830-V3
Unveiling the nanoscale organisation and dynamics of synaptic vesicle...
GA ID:
GA28830-V3
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Variation Publish Date:
20-Oct-2021
Variation Date:
12-Oct-2021
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
10-Jan-2019 to 9-Jan-2022
Value (AUD):
$668,000.00
(GST inclusive where applicable)
Varies:
GA28830
- Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Unveiling the nanoscale organisation and dynamics of synaptic vesicle pools
Purpose:
This project aims to uncover the role of key molecules in allowing brain cells to actively communicate with each other. Communication between neurons relies on the fusion of synaptic vesicles containing neurotransmitters with the presynaptic plasma membrane. The addition of vesicular membrane is transient as the vesicles quickly reform from the plasma membrane and refill with neurotransmitter ready for subsequent rounds of fusion. This recycling process ensures that neurons communicate efficiently, however the underpinning mechanism is unknown. This project aims to use a recently developed single synaptic vesicle super-resolution tracking method to establish how Myosin-VI and Synapsin-IIa orchestrate this recycling in central and peripheral neurons. It will explain how neurons manage to preserve their ability to communicate.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
ST LUCIA
Town/City:
ST LUCIA
Postcode:
4067
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
4067
Country:
AUSTRALIA