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Grant Award View - GA66004
Deciphering the structures and functions of LUBAC complexes in immune...
GA ID:
GA66004
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
12-Nov-2019
Publish Date:
16-Dec-2019
Category:
Health and Medical Research
Grant Term:
1-Jan-2020 to 31-Dec-2023
Value (AUD):
$1,074,524.09
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 18/19 1.1 Health and Medical Research
Grant Program:
Ideas
Grant Activity:
Deciphering the structures and functions of LUBAC complexes in immune signalling
Purpose:
The linear ubiquitin chain assembly complex (LUBAC) regulates the body’s immune response to infection. Mutations in the LUBAC cause inflammation and immunodeficiency, and the LUBAC may be a novel drug target to treat these diseases. In this project, we will decipher the three-dimensional structure of the LUBAC and its interactions with a novel regulator, FAM115A, to understand its role in immune signalling and inflammation, and open up avenues for future drug development.
GO ID:
GO Title:
Ideas Grants 2019
Internal Reference ID:
GNT1182757
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
Walter and Eliza Hall Institute of Medical Research
Recipient ABN:
12 004 251 423
Grant Recipient Location
Suburb:
Parkville
Town/City:
Parkville
Postcode:
3052
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
Country:
AUSTRALIA