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Grant Award View - GA65872
Looking beyond the exome: structural variation and gene dysregulation...
GA ID:
GA65872
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
12-Nov-2019
Publish Date:
16-Dec-2019
Category:
Health and Medical Research
Grant Term:
1-Jan-2020 to 31-Dec-2022
Value (AUD):
$860,662.06
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 18/19 1.1 Health and Medical Research
Grant Program:
Ideas
Grant Activity:
Looking beyond the exome: structural variation and gene dysregulation causing neurodegeneration
Purpose:
Inherited peripheral neuropathies (IPN) affect motor and sensory nerves resulting in lifelong chronic disability. We have identified a novel disease mechanism in which different DNA structural variation (SV) mutations cause gene dysregulation in two unrelated IPN families. We elucidate this novel mechanism for IPNs by identifying the causative dysregulated genes in patient motor neurons and modelling the gene dysregulation in whole organisms (C. elegans) to develop effective therapies.
GO ID:
GO Title:
Ideas Grants 2019
Internal Reference ID:
GNT1186867
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
ANZAC Research Institute
Recipient ABN:
48 066 780 005
Grant Recipient Location
Suburb:
Concord
Town/City:
Concord
Postcode:
2139
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
Country:
AUSTRALIA