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Grant Award View - GA65837
Understanding a novel pathway in genome stability: mTOR and F-actin...
GA ID:
GA65837
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
12-Nov-2019
Publish Date:
16-Dec-2019
Category:
Health and Medical Research
Grant Term:
1-Jan-2020 to 31-Dec-2022
Value (AUD):
$568,603.55
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 18/19 1.1 Health and Medical Research
Grant Program:
Ideas
Grant Activity:
Understanding a novel pathway in genome stability: mTOR and F-actin alter nuclear architecture to repair DNA replication stress
Purpose:
DNA replication is the process where the genomic material is copied before cell division. When DNA replication is stressed, this introduces genome instability that can drive cancer formation. We have discovered a new pathway where the mTOR kinase regulates polymerization of actin fibres to change nuclear architecture and facilitate repair of stressed DNA replication. In this project we will investigate this newly discovered pathway and its potential utility for cancer treatment.
GO ID:
GO Title:
Ideas Grants 2019
Internal Reference ID:
GNT1185870
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Sydney
Recipient ABN:
15 211 513 464
Grant Recipient Location
Suburb:
Camperdown
Town/City:
Camperdown
Postcode:
2050
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
Country:
AUSTRALIA