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Grant Award View - GA276581
Hijacking enzymes that charge tRNAs: a new strategy for development of...
GA ID:
GA276581
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
27-Oct-2022
Publish Date:
19-Dec-2022
Category:
Medical Research
Grant Term:
1-Jan-2023 to 31-Dec-2025
Value (AUD):
$758,942.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 21/22 1.1 Health and Medical Research
Grant Program:
Ideas Grants
Grant Activity:
Hijacking enzymes that charge tRNAs: a new strategy for development of anti-malarials.
Purpose:
New drugs are desperately needed to treat drug-resistant pathogens. We have discovered a class of inhibitor molecules, called “nukesâ€, that target enzymes powered by the energy molecule, ATP. “Nukes†induce the enzymes to generate their own inhibitors, via a mechanism that we call “reaction hijackingâ€. This project will investigate the design principles for making bespoke “nukesâ€, which will have applications in curing malaria, as well as infections with antimicrobial resistant bacteria.
GO ID:
GO Title:
Ideas Grants 2022
Internal Reference ID:
2022/GNT2019492
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Melbourne
Recipient ABN:
84 002 705 224
Grant Recipient Location
Suburb:
Parkville
Town/City:
Parkville
Postcode:
3052
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
ACT, VIC
Postcode:
Multiple
Country:
AUSTRALIA