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Grant Award View - GA215436-V1
The structural basis for MPEG1 mediated assembly of immune complexes
GA ID:
GA215436-V1
Agency:
Australian Research Council
Approval Date:
19-Jan-2022
Variation Publish Date:
4-Jul-2023
Variation Date:
20-Jun-2023
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
4-Mar-2022 to 3-Mar-2025
Value (AUD):
$550,958.00
(GST inclusive where applicable)
Varies:
GA215436
- The structural basis for MPEG1 mediated assembly of immune complexes
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 21/22 Discovery
Grant Program:
Discovery Projects
Grant Activity:
The structural basis for MPEG1 mediated assembly of immune complexes
Purpose:
Macrophage Expressed Gene-1 (MPEG1) is an ancient pore forming perforin-like immune effector that is found throughout multicellular life. In humans MPEG1 is found in Macrophages (a type of immune cell) and functions to eliminate a wide range of different infectious microbes. In this study we will study how different modifications and molecular interactions drive MPEG1 function. Crucially our work will provide a framework to understand how MPEG1 interacts with the interferon signalling pathway. These data will provide fundamental insight into how perforin-like proteins are controlled and will broadly inform new approaches to modify immune function and molecular signalling events.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2022
Internal Reference ID:
DP22 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
Monash University
Recipient ABN:
12 377 614 012
Grant Recipient Location
Suburb:
MULGRAVE
Town/City:
MULGRAVE
Postcode:
3170
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3170
Country:
AUSTRALIA