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Grant Award View - GA207601
Sex-differences in cellular aging and cardiovascular disease: Role of...
GA ID:
GA207601
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
3-Nov-2021
Publish Date:
4-Jan-2022
Category:
Medical Research
Grant Term:
1-Jan-2022 to 31-Dec-2025
Value (AUD):
$1,189,392.20
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 20/21 1.1 Health and Medical Research
Grant Program:
Ideas Grants
Grant Activity:
Sex-differences in cellular aging and cardiovascular disease: Role of the AngIV/IRAP axis
Purpose:
High blood pressure and ageing increase the risk of heart disease. Young women are protected from heart disease, but lose this protection with age. Senolytics are a new class of drug that remove damaged (senescent) cells from the body. Senescent cells lose the ability to self-repair and trigger a cascade of reactions to promote disease. We will determine if a novel enzyme insulin-regulated aminopeptidase (IRAP) causes cell damage and disease, and test the efficacy of IRAP inhibitors.
GO ID:
GO Title:
2021 Ideas Grants
Internal Reference ID:
2021/GNT2012552
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
Monash University
Recipient ABN:
12 377 614 012
Grant Recipient Location
Suburb:
Clayton
Town/City:
Clayton
Postcode:
3800
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
ACT, VIC
Postcode:
Multiple
Country:
AUSTRALIA