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Grant Award View - GA143437
ER stress-Unfolded Protein Response a critical metabolic pathway for...
GA ID:
GA143437
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
26-Nov-2020
Publish Date:
21-Dec-2020
Category:
Health and Medical Research
Grant Term:
1-Jan-2021 to 31-Dec-2023
Value (AUD):
$789,474.50
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 19/20 1.1 Health and Medical Research
Grant Program:
Ideas
Grant Activity:
ER stress-Unfolded Protein Response a critical metabolic pathway for airway remodelling in asthma
Purpose:
Airway remodelling in asthma is associated with poor clinical outcomes and is not prevented by current treatments. We have found endoplasmic reticulum stress (ERS) and associated unfolded protein response (UPR), a crucial process involve in cellular protein folding, play a key role in airway remodelling in asthma. This study will investigate whether inhibition of ERS prevents goblet cell metaplasia, mucus hypersecretion and fibrosis and can be used as a therapeutic strategy for severe asthma.
GO ID:
GO Title:
2020 Ideas Grants
Internal Reference ID:
GNT2002953
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Newcastle
Recipient ABN:
15 736 576 735
Grant Recipient Location
Suburb:
Callaghan
Town/City:
Callaghan
Postcode:
2308
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
Country:
AUSTRALIA