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Grant Award View - GA68375-V1
Antigen selection mechanisms control T cell immunity against bacteria
GA ID:
GA68375-V1
Agency:
Australian Research Council
Approval Date:
20-Dec-2019
Variation Publish Date:
1-Jun-2021
Variation Date:
1-Jun-2021
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Sep-2020 to 30-Aug-2023
Value (AUD):
$587,000.00
(GST inclusive where applicable)
Varies:
GA68375
- Antigen selection mechanisms control T cell immunity against bacteria
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 19/20 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Antigen selection mechanisms control T cell immunity against bacteria
Purpose:
CD4+ T (T helper) cells are required to control many important bacterial infections. This Project aims to identify the key targets of CD4+ T cells responding to a model bacterial infection, and to correlate potential antigen effectiveness with native expression, antigen presentation, and the function of antigen-specific CD4+ T cells over time. Our validated experimental 'pipeline' has unprecedented potential to define potent CD4+ T cell antigens within the thousands of proteins expressed by a bacterial pathogen. Our unbiased analysis may help establish the rules that define effective antigenicity. Our work will improve the understanding of bacterial immunity, and inform future design of T-cell based vaccines in the agricultural sector.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2020
Internal Reference ID:
DP20 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Melbourne
Recipient ABN:
84 002 705 224
Grant Recipient Location
Suburb:
UNIVERSITY OF MELBOURNE
Town/City:
UNIVERSITY OF MELBOURNE
Postcode:
3010
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3010
Country:
AUSTRALIA