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Grant Award View - GA67189
TLR7 mutations cause human monogenic lupus: Understanding mechanism to...
GA ID:
GA67189
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
12-Nov-2019
Publish Date:
20-Dec-2019
Category:
Health and Medical Research
Grant Term:
1-Jan-2020 to 31-Dec-2022
Value (AUD):
$725,060.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 18/19 1.1 Health and Medical Research
Grant Program:
Ideas
Grant Activity:
TLR7 mutations cause human monogenic lupus: Understanding mechanism to illuminate therapy.
Purpose:
Systemic lupus erythematosus is a multiorgan autoimmune disease with a strong genetic basis. We have identified novel or rare variants in the X linked gene TLR7 in autoimmune patients and show their pathogenicity by expressing an orthologous variant in mice. This is the first evidence that TLR7 variants cause monogenic human disease. We plan to unravel the cellular and molecular basis by which the variants alter protein function and drive disease in order to develop more effective treatments.
GO ID:
GO Title:
Ideas Grants 2019
Internal Reference ID:
GNT1184242
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
Australian National University
Recipient ABN:
52 234 063 906
Grant Recipient Location
Suburb:
Canberra City
Town/City:
Canberra City
Postcode:
2601
State/Territory:
ACT
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
ACT
Postcode:
Country:
AUSTRALIA