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Grant Award View - GA143482
Harnessing Extracellular Matrix Remodelling by Cancer-Associated...
GA ID:
GA143482
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
26-Nov-2020
Publish Date:
21-Dec-2020
Category:
Health and Medical Research
Grant Term:
1-Jan-2021 to 31-Dec-2024
Value (AUD):
$923,407.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 19/20 1.1 Health and Medical Research
Grant Program:
Ideas
Grant Activity:
Harnessing Extracellular Matrix Remodelling by Cancer-Associated Fibroblasts to Increase T Cell Infiltration of Solid Tumours
Purpose:
The ability of killer T cells to find and eliminate tumour cells is the basis for adoptive transfer immunotherapies, which thus far only work well with blood-borne cancers. There is limited success with solid tumours, which T cells do not readily infiltrate, notably because of remodelling by fibroblasts. We have discovered that T cells migrate in tunnels dug in the tumour matrix by fibroblasts. Here, we will harness this discovery to improve tumour infiltration and rejection of solid tumours.
GO ID:
GO Title:
2020 Ideas Grants
Internal Reference ID:
GNT2003139
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of New South Wales
Recipient ABN:
57 195 873 179
Grant Recipient Location
Suburb:
Sydney
Town/City:
Sydney
Postcode:
2052
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
Country:
AUSTRALIA