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Grant Award View - GA141014-V4
Signaling in the crypt: a novel metabolic pathway in intestinal stem...
GA ID:
GA141014-V4
Agency:
Australian Research Council
Approval Date:
2-Dec-2020
Variation Publish Date:
20-Oct-2021
Variation Date:
1-Dec-2021
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Dec-2021 to 30-Nov-2024
Value (AUD):
$472,496.00
(GST inclusive where applicable)
Varies:
GA141014
- Signaling in the crypt: a novel metabolic pathway in intestinal stem cells
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 20/21 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Signaling in the crypt: a novel metabolic pathway in intestinal stem cells
Purpose:
The gut is the most rapidly renewing tissue in the body, driven by a highly active stem cell niche. Bile acids are emerging as critical regulators of this stem cell niche and disruption of bile acid homeostasis has profoundly adverse effects on intestinal renewal and hence gut health. We are addressing a critical gap in our understanding of how bile acids are controlled within stem cell niche. The aim of the project is to define the critical role of a novel enzyme called UGT8 in controlling intestinal stem cell response to bile acids; this is achieved by modulating UGT8 activity in intestinal stem cell models and determining the effects on stem cell function and the key signalling pathways that control intestinal homeostasis and renewal.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2021
Internal Reference ID:
DP21 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
Flinders University
Recipient ABN:
65 542 596 200
Grant Recipient Location
Suburb:
BEDFORD PARK
Town/City:
BEDFORD PARK
Postcode:
5042
State/Territory:
SA
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
SA
Postcode:
5042
Country:
AUSTRALIA