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Grant Award View - GA142194-V1
Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
GA ID:
GA142194-V1
Agency:
Australian Research Council
Approval Date:
11-Dec-2020
Variation Publish Date:
28-Apr-2021
Variation Date:
28-Apr-2021
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Mar-2021 to 29-Feb-2024
Value (AUD):
$498,000.00
(GST inclusive where applicable)
Varies:
GA142194
- Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 20/21 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
Purpose:
This project aims to understand the use of the steroid cholesterol as a source of essential metabolic building blocks by bacteria. Cholesterol utilisation is a key feature of many bacterial pathogens which have evolved to survive in niche environments. By understanding the initial step in cholesterol degradation and the bioinorganic and bioorganic chemistry of the metalloenzymes that catalyse it, this work aims to develop strategies to block this activity. This will turn a key strength of these bacteria into a potent weakness and will generate the proof of principle and knowledge required for the future development of effective strategies to combat pathogenic bacteria.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2021
Internal Reference ID:
DP21 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
ST LUCIA
Town/City:
ST LUCIA
Postcode:
4067
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
4067
Country:
AUSTRALIA