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Grant Award View - GA205203
The Single Cell Basis for the Emergence of Drug Resistance during...
GA ID:
GA205203
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
3-Nov-2021
Publish Date:
13-Dec-2021
Category:
Medical Research
Grant Term:
1-Jan-2022 to 31-Dec-2025
Value (AUD):
$1,200,569.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 20/21 1.1 Health and Medical Research
Grant Program:
Ideas Grants
Grant Activity:
The Single Cell Basis for the Emergence of Drug Resistance during Azacitidine Therapy in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Purpose:
Myelodysplasia and acute myeloid leukemia are blood cancers that arise in abnormal blood stem cells in the bone marrow. Azacitidine (AZA) is a drug that helps re-establish blood cell production in ~50% of patients. It is ineffective in the remainder. We will test whether AZA works in responders by improving the fitness of abnormal blood stem cells and their surrounding cells and modulating immune cells that help eliminate abnormal blood cells. This will guide drug discovery for non-responders.
GO ID:
GO Title:
2021 Ideas Grants
Internal Reference ID:
2021/GNT2011627
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of New South Wales
Recipient ABN:
57 195 873 179
Grant Recipient Location
Suburb:
Sydney
Town/City:
Sydney
Postcode:
2052
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
ACT, NSW, Overseas
Postcode:
Multiple
Country:
AUSTRALIA, NEW ZEALAND, UNITED KINGDOM