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Grant Award View - GA2144

Understanding how RNA editing regulates RNA fate

Contact Details

ARC NCGP General Enquiries

Phone:
02 6281 6600

Email Address:

GA ID:
GA2144
Agency:
Australian Research Council
Approval Date:
10-Nov-2017
Publish Date:
20-Feb-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2018 to 31-Dec-2020
Value (AUD):
$467,883.90 (GST inclusive where applicable)

Ad hoc/One-off:
No
Aggregate Grant Award:
No

PBS Program Name:
ARC 17/18 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Understanding how RNA editing regulates RNA fate
Purpose:
This project aims to address how RNA editing mediated by ADAR1 alters the interactions of targeted RNA with the innate immune sensing system. ADAR1 editing converts adenosine to inosine within double stranded RNA. It is known that this is key to prevent activation of the innate immune sensor MDA5 by endogenous RNA. However, we do not understand why edited RNA is tolerated and unedited RNA is not. This project will generate new knowledge regarding the effect of editing on how endogenous RNA is perceived by the innate immune system.

Internal Reference ID:
DP18 Round 1
Selection Process:
Targeted or Restricted Competitive

Confidentiality - Contract:
No
Confidentiality - Outputs:
No

Grant Recipient Details

Recipient Name:
Australian Catholic University
Recipient ABN:
15 050 192 660

Grant Recipient Location

Suburb:
NORTH SYDNEY
Town/City:
NORTH SYDNEY
Postcode:
2060
State/Territory:
NSW
Country:
AUSTRALIA

Grant Delivery Location

State/Territory:
NSW
Postcode:
2060
Country:
AUSTRALIA

Contact Details

ARC NCGP General Enquiries

Phone:
02 6281 6600

Email Address: