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Grant Award View - GA68503
Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance
GA ID:
GA68503
Agency:
Australian Research Council
Approval Date:
20-Dec-2019
Publish Date:
6-Jan-2020
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2020 to 31-Dec-2022
Value (AUD):
$605,000.00
(GST inclusive where applicable)
Variations:
- GA68503-V2 - Variation to Grant (20-Oct-2021 )
- GA68503-V1 - Variation to Grant (2-Aug-2021 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 19/20 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Augmenting the activity of glyoxalase-1 to increase dicarbonyl clearance
Purpose:
Reactive intermediates generated during our metabolism contribute to ageing. Glyoxalase-1 is a key defence enzyme against these toxic intermediates and therefore ageing itself. This project aims to investigate novel pathways how the expression and activity of glyoxalase-1 are regulated. This interdisciplinary project expects to generate new understanding by combining relevant cell and animal models, protein chemistry, epigenetics and structural biology. It is expected that this work will improve understanding of this fundamental biological defence. This will allow us to identify the potential means to enhance the capacity of glyoxalase-1 to the future benefit of biological ageing.
GO ID:
GO Title:
Discovery Projects for funding commencing in 2020
Internal Reference ID:
DP20 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
Monash University
Recipient ABN:
12 377 614 012
Grant Recipient Location
Suburb:
MULGRAVE
Town/City:
MULGRAVE
Postcode:
3170
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3170
Country:
AUSTRALIA