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Grant Award View - GA29061
The structural basis for defensin-mediated membrane attack
GA ID:
GA29061
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Publish Date:
18-Dec-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2019 to 31-Dec-2023
Original: 1-Jan-2019 to 31-Dec-2021
Value (AUD):
$412,000.00
(GST inclusive where applicable)
Variations:
- GA29061-V4 - Variation to Grant (2-Aug-2023 )
- GA29061-V3 - Variation to Grant (21-Jun-2022 )
- GA29061-V2 - Variation to Grant (20-Oct-2021 )
- GA29061-V1 - Variation to Grant (2-Aug-2021 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
The structural basis for defensin-mediated membrane attack
Purpose:
This project aims to define how the innate defense proteins called defensins attack target membranes to cause cells to burst and die. It is often said that attack is the best form of defense, and the immune systems of plants and animals will often target the cell membranes of microbes and other pathogens to defend themselves. This project will identify the precise molecular mechanism underlying defensin activity, and clarify how ligand recognition and subsequent multimerisation leads to target membrane lysis. The project will establish the fundamental mechanisms regulating antimicrobial defense systems based on small proteins, and define a conceptual framework for the action of defensins to develop strategies to combat fungal infections.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
La Trobe University
Recipient ABN:
64 804 735 113
Grant Recipient Location
Suburb:
BUNDOORA
Town/City:
BUNDOORA
Postcode:
3086
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3086
Country:
AUSTRALIA