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Grant Award View - GA28948
Sinusoidal voltage protocols for characterisation of ion channel...
GA ID:
GA28948
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Publish Date:
18-Dec-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2019 to 30-Jun-2023
Original: 1-Jan-2019 to 31-Dec-2021
Value (AUD):
$409,000.00
(GST inclusive where applicable)
Variations:
- GA28948-V4 - Variation to Grant (17-May-2023 )
- GA28948-V3 - Variation to Grant (21-Jun-2022 )
- GA28948-V2 - Variation to Grant (20-Oct-2021 )
- GA28948-V1 - Variation to Grant (2-Aug-2021 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Sinusoidal voltage protocols for characterisation of ion channel kinetics
Purpose:
This project aims to implement an innovative approach to modelling ion channel behaviour that employs short, information-rich datasets and parameter inference. Using the hERG potassium channel as a test case, the project will show that this approach is more efficient than current methods and outperforms all published models in independent validations. The project aims to extend on initial implementation to probe the thermodynamics and pharmacology of ion channel gating. The anticipated outcomes are to grow fundamental knowledge of ion channel biophysics and ability to probe ion channel function in silico. The project will build on an emerging collaboration between international leaders in physiology, pharmacology, mathematics and computer modelling. The methodology and fundamental knowledge generated will significantly advance our understanding of the physiology and biophysics of ion channels, while the application of the method will have direct impact in the pharmaceutical industry and regulatory science.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of New South Wales
Recipient ABN:
57 195 873 179
Grant Recipient Location
Suburb:
KENSINGTON
Town/City:
KENSINGTON
Postcode:
2033
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
2033
Country:
AUSTRALIA