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Grant Award View - GA28597
Chemical-biology approaches to pathway selective adenosine receptor...
GA ID:
GA28597
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Publish Date:
18-Dec-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jul-2019 to 30-Jun-2023
Original: 1-Jan-2019 to 31-Dec-2021
Value (AUD):
$450,000.00
(GST inclusive where applicable)
Variations:
- GA28597-V5 - Variation to Grant (28-Sep-2022 )
- GA28597-V4 - Variation to Grant (5-Jul-2022 )
- GA28597-V3 - Variation to Grant (20-Oct-2021 )
- GA28597-V2 - Variation to Grant (2-Aug-2021 )
- GA28597-V1 - Variation to Grant (15-Jan-2019 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Chemical-biology approaches to pathway selective adenosine receptor ligands
Purpose:
This project aims to develop new chemical-biology tools and approaches for selectively targeting signalling pathways mediated by G protein-coupled receptors (GPCR). GPCRs are an important family of cell surface signalling proteins that are responsible for the regulation of numerous vital physiological functions. The A1 adenosine receptor is an important model and therapeutically relevant GPCR that will be the focus of this project. Compounds known as bitopic ligands, which can interact with distinct binding sites (termed orthosteric and allosteric sites), will be explored as pathway selective agents capable of activating the signalling pathways mediating the desired effect in preference to those producing adverse effects. Longer-term benefits include the identification of bioactive compounds with more selective modes of action and improved safety profiles.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
Monash University
Recipient ABN:
12 377 614 012
Grant Recipient Location
Suburb:
MULGRAVE
Town/City:
MULGRAVE
Postcode:
3170
State/Territory:
VIC
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
VIC
Postcode:
3170
Country:
AUSTRALIA