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Grant Award View - GA28563
Mechanobiology: a new model of integrin activation by membrane tension
GA ID:
GA28563
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Publish Date:
18-Dec-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jul-2019 to 30-Jun-2022
Original: 1-Jan-2019 to 31-Dec-2021
Value (AUD):
$368,000.00
(GST inclusive where applicable)
Variations:
- GA28563-V3 - Variation to Grant (14-Oct-2021 )
- GA28563-V2 - Variation to Grant (2-Aug-2021 )
- GA28563-V1 - Variation to Grant (9-Jul-2019 )
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Early Career Researcher Award
Grant Activity:
Mechanobiology: a new model of integrin activation by membrane tension
Purpose:
This project aims to address a fundamental question in mechanobiology on how integrin receptor coordinates with force to mediate cell spreading, migration, growth and survival. With an observation that membrane deformation enhances integrin binding, the project expects to establish a new model of integrin activation by membrane tension. It will develop an integrated approach combining single-molecule force probes, super resolution microscopy, microfluidics and molecular dynamics simulations. It is expected that the role of membrane tension in promoting cell adhesion will be defined at molecular scale, and the link between integrin activation and Piezo calcium channel mediated membrane tension sensing will be delineated.
GO ID:
GO Title:
Discovery Early Career Researcher Award commencing in 2019
Internal Reference ID:
DE19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Sydney
Recipient ABN:
15 211 513 464
Grant Recipient Location
Suburb:
FOREST LODGE
Town/City:
FOREST LODGE
Postcode:
2037
State/Territory:
NSW
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
NSW
Postcode:
2037
Country:
AUSTRALIA