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Grant Award View - GA28462

Cysteamine dioxygenases: novel oxygen sensors implicated in hypoxia?

Contact Details

ARC NCGP General Enquiries

Phone:
02 6281 6600

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GA ID:
GA28462
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Publish Date:
18-Dec-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
17-May-2019 to 16-May-2022
Original: 1-Jan-2019 to 31-Dec-2021
Value (AUD):
$422,574.00 (GST inclusive where applicable)
Variations:

Ad hoc/One-off:
No
Aggregate Grant Award:
No

PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Early Career Researcher Award
Grant Activity:
Cysteamine dioxygenases: novel oxygen sensors implicated in hypoxia?
Purpose:
This project aims to characterise and manipulate a novel oxygen sensing system, the cysteamine dioxygenases, to help understand how mammalian cells respond to low oxygen concentrations, a condition known as hypoxia. A number of the world’s most destructive diseases can impair oxygen delivery, altering biochemical landscapes. By understanding how cells respond to fluctuations in oxygen, the project expects to develop effective methods to treat these detrimental conditions. Characterisation of the cysteamine dioxygenases could establish a novel mechanism by which cells monitor changes in oxygen, assisting in understanding hypoxia and disease. The project will also enable new cysteine initiating substrates to be identified, allowing the full impact of this regulatory process to be appreciated in mammals.

Internal Reference ID:
DE19 Round 1
Selection Process:
Targeted or Restricted Competitive

Confidentiality - Contract:
No
Confidentiality - Outputs:
No

Grant Recipient Details

Recipient Name:
The University of Sydney
Recipient ABN:
15 211 513 464

Grant Recipient Location

Suburb:
FOREST LODGE
Town/City:
FOREST LODGE
Postcode:
2037
State/Territory:
NSW
Country:
AUSTRALIA

Grant Delivery Location

State/Territory:
NSW
Postcode:
2037
Country:
AUSTRALIA

Contact Details

ARC NCGP General Enquiries

Phone:
02 6281 6600

Email Address: