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Grant Award View - GA28369

Biosynthetic LEGO: enzymatic redesign to produce new vancomycin...

Contact Details

ARC NCGP General Enquiries

Phone:
02 6281 6600

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GA ID:
GA28369
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Publish Date:
18-Dec-2018
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
1-Jan-2019 to 31-Dec-2021
Value (AUD):
$480,000.00 (GST inclusive where applicable)

Ad hoc/One-off:
No
Aggregate Grant Award:
No

PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
Biosynthetic LEGO: enzymatic redesign to produce new vancomycin analogues
Purpose:
This project aims to uncover the reengineering potential of the biosynthetic machinery that produces glycopeptide antibiotics by advancing our understanding of how the core peptide production line functions. Natural product biosynthesis often produces complex peptide structures, with one important example being the glycopeptide antibiotics. This project expects to generate new knowledge about enzymatic peptide biosynthesis using a highly interdisciplinary approach and previously developed tools. The anticipated outcomes of this project will be an enhanced understanding of how such complex peptide biosynthesis is performed, which is knowledge vital for future efforts to reengineer such biosynthetic peptide assembly lines as a series of modular LEGO blocks to produce new bioactive peptides.

GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive

Confidentiality - Contract:
No
Confidentiality - Outputs:
No

Grant Recipient Details

Recipient Name:
Monash University
Recipient ABN:
12 377 614 012

Grant Recipient Location

Suburb:
CLAYTON
Town/City:
CLAYTON
Postcode:
3168
State/Territory:
VIC
Country:
AUSTRALIA

Grant Delivery Location

State/Territory:
VIC
Postcode:
3168
Country:
AUSTRALIA

Contact Details

ARC NCGP General Enquiries

Phone:
02 6281 6600

Email Address: