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Grant Award View - GA28640-V1
RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
GA ID:
GA28640-V1
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Variation Publish Date:
9-Jul-2019
Variation Date:
9-Jul-2019
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
10-Jan-2019 to 9-Jan-2023
Value (AUD):
$746,400.00
(GST inclusive where applicable)
Varies:
GA28640
- RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
Purpose:
This project aims to elucidate a new paradigm for regulating cell signals at the nanoscale level. Cell signalling involves the coordination of multi-molecular networks at the plasma membrane, the interface between the cell and its external environment. These are often thought to involve the assembly of multimolecular complexes through the action of protein scaffolds. This project will focus on how the contractile regulator, anillin, controls RhoA signalling by kinetic regulation. In particular, how nanoscale clustering of anillin by the dynamic actomyosin cytoskeleton modulates RhoA signalling for contractility and tissue homeostasis. The outcomes of this project are first and foremost fundamental understanding of how cells communicate with one another.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
ST LUCIA
Town/City:
ST LUCIA
Postcode:
4067
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
4067
Country:
AUSTRALIA