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Grant Award View - GA28482-V1
How tissues generate the peptide hormone angiotensin II
GA ID:
GA28482-V1
Agency:
Australian Research Council
Approval Date:
27-Nov-2018
Variation Publish Date:
9-Jul-2019
Variation Date:
9-Jul-2019
Category:
Science, Technology, Engineering and Mathematics (STEM) Research
Grant Term:
10-Jan-2019 to 9-Jan-2022
Value (AUD):
$445,000.00
(GST inclusive where applicable)
Varies:
GA28482
- How tissues generate the peptide hormone angiotensin II
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
ARC 18/19 Discovery
Grant Program:
Discovery Projects
Grant Activity:
How tissues generate the peptide hormone angiotensin II
Purpose:
This project aims to investigate how local tissue renin-angiotensin systems operate. A blood-borne renin–angiotensin system (RAS) produces a peptide (AngII) to control blood pressure, and fluid/salt balance. Many tissues, such as the brain and heart, also possess an independent, tissue RAS, but how these function is not well understood. The project will use a model whereby infiltrating macrophages (following damage to the heart) drive the activation of this system to trigger the local generation of AngII. This project addresses the question of where exactly in the heart the RAS components are turned on, how they interact to generate AngII and whether the activation of the local RAS is beneficial or not to cardiac function. The findings should provide critical insights into an important hormonal system.
GO ID:
GO Title:
Discovery Projects commencing in 2019
Internal Reference ID:
DP19 Round 1
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
No
Confidentiality - Outputs:
No
Grant Recipient Details
Recipient Name:
The University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
ST LUCIA
Town/City:
ST LUCIA
Postcode:
4067
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
4067
Country:
AUSTRALIA