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Grant Award View - GA29951
Unravelling how exosomes induce and propagate tau pathology
GA ID:
GA29951
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
25-Oct-2018
Publish Date:
21-Dec-2018
Category:
Medical Research
Grant Term:
1-Jan-2019 to 31-Dec-2021
Value (AUD):
$827,521.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 17/18 1.1 Health and Medical Research
Grant Program:
Project
Grant Activity:
Unravelling how exosomes induce and propagate tau pathology
Purpose:
We have established that brains from mice with tau pathology produce tau seeds 'encapsulated' within extracellular vesicles known as exosomes. Furthermore, exosomes containing tau seeds can induce tau aggregation in recipient cells, and exosomes spread from neuron to neuron by hijacking endosomes. We aim to determine how exosomal tau seeds escape endosomes, and whether controlling the exosome production or traffic can halt or reduce tau pathology.
GO ID:
GO Title:
NHMRC Project Grant Scheme
Internal Reference ID:
GNT1161133
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
St Lucia
Town/City:
St Lucia
Postcode:
4072
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
Country:
AUSTRALIA