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Grant Award View - GA29835
Intestinal barrier integrity in dengue virus infection
GA ID:
GA29835
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
25-Oct-2018
Publish Date:
21-Dec-2018
Category:
Medical Research
Grant Term:
1-Jan-2019 to 31-Dec-2021
Value (AUD):
$713,346.20
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 17/18 1.1 Health and Medical Research
Grant Program:
Project
Grant Activity:
Intestinal barrier integrity in dengue virus infection
Purpose:
Mosquito-borne dengue virus is a major health threat in tropical areas. We found that the virus causes pathology in a similar manner to some bacterial infections, via a cell surface receptor called TLR4. We have used drugs to block TLR4, and this greatly reduced disease severity in a mouse model of infection. Blocking TLR4 prevents leakiness of blood vessels and inflammatory damage in the gut and is promising as a treatment to reduce hospitalisation.
GO ID:
GO Title:
NHMRC Project Grant Scheme
Internal Reference ID:
GNT1163313
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
St Lucia
Town/City:
St Lucia
Postcode:
4072
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
Country:
AUSTRALIA