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Grant Award View - GA29815
Molecular basis and inhibition of TIR-domain function in Toll-like...
GA ID:
GA29815
Agency:
National Health and Medical Research Council (NHMRC)
Approval Date:
25-Oct-2018
Publish Date:
21-Dec-2018
Category:
Medical Research
Grant Term:
1-Jan-2019 to 31-Dec-2021
Value (AUD):
$772,521.00
(GST inclusive where applicable)
One-off/Ad hoc:
No
Aggregate Grant Award:
No
PBS Program Name:
NHMRC 17/18 1.1 Health and Medical Research
Grant Program:
Project
Grant Activity:
Molecular basis and inhibition of TIR-domain function in Toll-like receptor and neuronal cell-death pathways
Purpose:
A protein domain called TIR domain plays key roles in signalling in innate immunity pathways, associated with chronic inflammatory diseases, and the axon degeneration pathway, a pathway central to neurodegenerative disorders. We found that TIR domains form large assemblies and at least in some cases possess enzymatic activity. Through characterizing the molecular details of these functions, we will uncover ways to inhibit them and provide a foundation for developing a range of therapeutics.
GO ID:
GO Title:
NHMRC Project Grant Scheme
Internal Reference ID:
GNT1160570
Selection Process:
Targeted or Restricted Competitive
Confidentiality - Contract:
Yes
Confidentiality Reason(s) - Contract:
Privacy Act 1988
Intellectual property
Intellectual property
Confidentiality - Outputs:
Yes
Confidentiality Reason(s) - Outputs:
Intellectual property
Grant Recipient Details
Recipient Name:
University of Queensland
Recipient ABN:
63 942 912 684
Grant Recipient Location
Suburb:
St Lucia
Town/City:
St Lucia
Postcode:
4072
State/Territory:
QLD
Country:
AUSTRALIA
Grant Delivery Location
State/Territory:
QLD
Postcode:
Country:
AUSTRALIA